Welcome to Reader Training

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Reader Training is an educational resource from Telix Pharmaceuticals, makers of Illuccix® (kit for the preparation of gallium Ga 68 gozetotide Injection), designed to improve PSMA-11 PET/CT reader skills and increase confidence in identifying pathology while following guidelines to optimize PET/CT reading. Learning modules will include, learning objectives, case study reviews and teaching points presented with video, slides, supporting resources and clinical articles.

Target Audience: NM physicians, radiologists, urologists, radiation oncologists, oncologists, surgeons, & referring physicians.

To view the Illuccix® full prescribing information visit Illuccix.com

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Module 3 - Part Three: Advanced Reading Skills: A Comprehensive PSMA-11 PET/CT Case Study Review
Presented by: Stefano Fanti, MD | Andrea Farolfi, MD
20018

Part 3 of this PSMA Reader Training module is a continuation of this program and is designed assist the reader in reading PSMA PET/CT with confidence, navigating challenging cases, addressing pitfalls, providing clear direction for patient management in the PSMA PET/CT report, and developing skills to become a consultant to the referring physician(s).

Teaching Points

  • Increase the PSMA PET/CT reader’s skill through a comprehensive case study review of advanced disease and unusual pathology.
  • Improve confidence of the findings through a determined review of the patient’s history and medical record, which support the need for a 68Ga PSMA-11 PET/CT scan.
  • Navigate challenging cases and develop a concise PSMA PET report.
  • Review 13 case study examples that demonstrate the clinical utility of 68Ga PSMA-11 PET/CT and improve reader confidence.

Note: “Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module.

Module 3 - Part Two: Advanced Reading Skills: A Comprehensive PSMA-11 PET/CT Case Study Review
Presented by: Stefano Fanti, MD | Andrea Farolfi, MD
20013

Part 2 of this PSMA Reader Training module is a continuation of Part 1 and designed to assist the reader in reading PSMA PET/CT with confidence by navigating challenging cases, addressing pitfalls, providing clear direction for patient management in the PSMA PET/CT report, and developing skills to become a consultant to the referring physician(s).

Teaching Points

  • Increase the PSMA PET/CT reader’s skill through a comprehensive case study review of complicated cases.
  • Address pitfalls that may occur when navigating challenging cases.
  • Develop a comprehensive and concise PSMA PET report to support the management of disease
  • Review 10 case study examples that demonstrate the clinical utility of 68Ga PSMA-11 PET/CT and improve reader confidence.

Note: “Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module.

Module 3 - Part One: Advanced Reading Skills: A Comprehensive PSMA-11 PET/CT Case Study Review
Presented by: Stefano Fanti, MD | Andrea Farolfi, MD
20006

Part 1 of this PSMA Reader Training module is designed assist the reader in reading PSMA PET/CT with confidence by navigating challenging cases, addressing pitfalls, providing clear direction for patient management in the PSMA PET/CT report, and developing skills to become a consultant to the referring physician(s).

Teaching Points

  • Increase the PSMA PET/CT reader’s skill through a comprehensive case study review of interesting cases.
  • Establish a methodical approach to reviewing image findings of PSMA PET/CT scans.
  • Develop a concise PSMA PET report.
  • Review 10 case study examples that demonstrate the clinical utility of 68Ga PSMA-11 PET/CT and improve reader confidence.

Note: “Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module.

Meet the Faculty

Stefano Fanti, M.D. Stefano Fanti, M.D.
Full Professor, Diagnostic Imaging at University of Bologna,
Director, Nuclear Medicine Division and PET Center, The Policlinico S. Orsola
Director, Specialty School of Nuclear Medicine, University of Bologna, Bologna, Italy

Dr. Fanti’s fields of interest include PET/CT imaging in oncology, innovative PET tracer development. Dr. Fanti has authored more than 1000 publications, including 520 original papers in international peer-reviewed journals, more than 700 abstracts, 30 books or chapters; H-index = 65; and has been an invited speaker in more than 120 international meetings.

Andrea Farolfi, MD Andrea Farolfi, M.D.
Division of Nuclear Medicine,
S. Orsola Hospital,
IRCCS Azienda Ospedaliero-Universitaria
Bologna, Italy

Dr. Farolfi graduated the University of Bologna in 2014 and began work in 2016 at the PET Unit at S.Orsola Policlinic Hospital, IRCCS Azienda Ospedaliero-Universitaria di Bologna. He is actively involved in both clinical routine and research area, with a particular interest for prostate cancer imaging. He is a full-time permanent nuclear medicine physician in the Division of Nuclear Medicine and has authored 24 scientific papers indexed on Scopus. H-index of 8 on Google Scholar, 6 on Scopus and has been an invited lecturer at more than 10 national and international meetings.

Module 2 - Considerations for 68Ga-PSMA-11 PET/CT Imaging Interpretation
Presented by: Jaideep Sohi, MD
19981

This PSMA Reader Training module is designed to improve PSMA PET/CT reader skills and increase the reader’s confidence by reviewing; the PSMA expression scoring, providing an understanding of how 68GA PSMA-11 varies from other PET Tracers (FDG, Choline, Fluciclovine), determining normal vs abnormal findings, explaining tips to navigate challenging 68GA PSMA-11 PET/CT cases, and developing the consultative role of the interpreting physician.

Teaching Points

  • Implement 68Ga-PSMA-11 PET/CT Imaging Interpretation Skills
  • Understand the Biodistribution of 68Ga-PSMA-11 PET/CT
  • Review 68Ga-PSMA-11 PET/CT Case Studies with Teaching Points
  • Develop the Consultative Role of the Interpreting Physician
  • Follow a Consistent Reading Format
    • Review attenuation corrected and non-attenuation corrected PET images to look for artifacts and to confirm finding.
    • Correlate with relevant prior imaging studies such as bone scans, CT, and MRIs etc.
    • Review PET imaging in narrow and wide windowing to evaluate lesions involving/adjacent to tissues with high background activity.

Note: Competency measurements in the form of a short online knowledge assessment exam, will be presented upon completion.

Meet the Faculty

Jaideep S. Sohi, M.D. PhotoJaideep S. Sohi, M.D.
President and Founder
American Molecular Imaging

Dr. Jaideep S. Sohi completed his residency training at one of the nation’s top-rated programs at the University of Iowa, where he also served as Chief Resident. Following residency, he completed a prestigious one-year PET/CT Fellowship at Johns Hopkins University

With over 15 years of high-level experience in the fields of PET/CT, diagnostic and therapeutic nuclear medicine, Dr. Sohi is passionate about working closely with referring providers and patients to provide exceptional quality of care. At the same time, he is actively involved in educating his colleagues regarding new imaging tracers by engaging in comprehensive clinical outreach programs.

Dr. Sohi currently serves as the president of American Molecular Imaging, as well as assistant professor of nuclear medicine at the California Northstate University School of Medicine.

Module 1 - Part Two: The Basics of 68Ga PSMA-11 PET/CT
Presented by: Nat Lenzo, MMed, MSc(Oncol)
19979

This PSMA Reader Training Module 1 | Part Two is a continuation of Part One. Part two provides additional basic learning and understanding of the clinical applications of 68Ga PSMA-11 PET/CT scans; develops skills to effectively read 68Ga PSMA-11 PET/CT scans, reviews the process for reading scans, provides the basis for implementing scanning protocols for 68Ga PSMA-11 PET/CT, and specifies when to order 68Ga PSMA-11.

Teaching Points

  • Provides an overview of 68Ga PSMA-11 PET Imaging.
  • Reviews a number of publications demonstrating clinical efficacy, safety, and experience of 68Ga PSMA-11.
  • Describes the differences of 68Ga PSMA-11 from other PET Tracers (FDG, Choline, Fluciclovine).
  • Compares PET/CT imaging with other imaging modalities (Bone Scan, MRI, CT).
  • Demonstrates the clinical impact of 68Ga PSMA-11 PET/CT in clinical staging and management of Prostate cancer.
  • Improves reader confidence through comprehensive case study reviews of 68Ga PSMA-11 PET/CT reading, interpretation, and clinical utility.

Note: “Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module.

Module 1 - Part One: The Basics of 68Ga PSMA-11 PET/CT
Presented by: Nat Lenzo, MMed, MSc(Oncol)
19978

This PSMA Reader Training Module 1 | Part One provides a basic understanding of the clinical applications of 68Ga PSMA-11 PET/CT scans; develops skills to effectively read 68Ga PSMA-11 PET/CT scans, reviews the process for reading scans, provides the basis for implementing scanning protocols for 68Ga PSMA-11 PET/CT, and specifies when to order 68GAa PSMA-11.

Teaching Points

  • Provides an overview of 68Ga PSMA-11 PET Imaging.
  • Reviews a number of publications demonstrating clinical efficacy, safety, and experience of 68Ga PSMA-11.
  • Describes the differences of 68Ga PSMA-11 from other PET Tracers (FDG, Choline, Fluciclovine).
  • Compares PET/CT imaging with other imaging modalities (Bone Scan, MRI, CT).
  • Demonstrates the clinical impact of 68Ga PSMA-11 PET/CT in clinical staging and management of Prostate cancer.
  • Improves reader confidence through comprehensive case study reviews of 68Ga PSMA-11 PET/CT reading, interpretation, and clinical utility.

Note: “Test Your Knowledge” competency measurements in the form of quiz questions, will be displayed throughout the module.

Meet the Faculty

Nat Lenzo, MD Photo Nat Lenzo, M.D.
Clinical Director of Theranostics and Molecular Imaging
Genesis Care

Dr. Lenzo graduated in medicine from the University of Western Australia and completed a fellowship in nuclear medicine at the University of Michigan. Apart from undergraduate science, research, and medical degrees, he also holds master’s degrees in medicine, oncology, health service management and business administration. Dr Lenzo has authored more than 200 publications including over 50 scientific papers in international peer-reviewed journals (H index 21).

In 2015, Dr. Lenzo founded Theranostics Australia, now fully owned by GenesisCare, where he remains in the position of group clinical director. He is committed to expanding the field of theranostics with GenesisCare in Australia and overseas.

IMPORTANT SAFETY INFORMATION

Risk for Misdiagnosis: Image interpretation errors can occur with gallium Ga 68 gozetotide PET. A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer. The performance of gallium Ga 68 gozetotide for imaging of biochemically recurrent prostate cancer seems to be affected by serum PSA levels and by site of disease. The performance of gallium Ga 68 gozetotide for imaging of metastatic pelvic lymph nodes prior to initial definitive therapy seems to be affected by Gleason score. Gallium Ga 68 gozetotide uptake is not specific for prostate cancer and may occur with other types of cancer as well as non-malignant processes such as Paget’s disease, fibrous dysplasia, and osteophytosis. Clinical correlation, which may include histopathological evaluation of the suspected prostate cancer site, is recommended.

  • with suspected metastasis who are candidates for initial definitive therapy
  • with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level

INDICATIONS AND USAGE

Illuccix®, after radiolabeling with Ga 68, is a radioactive diagnostic agent indicated for positron emission tomography (PET) of prostate-specific membrane antigen (PSMA) positive lesions in men with prostate cancer: 

  • with suspected metastasis who are candidates for initial definitive therapy

  • with suspected recurrence based on elevated serum prostate-specific antigen (PSA) level

Important Safety Information

CONTRAINDICATIONS

None

WARNINGS AND PRECAUTIONS

Risk for Misdiagnosis: Image interpretation errors can occur with gallium Ga 68 gozetotide PET. A negative image does not rule out the presence of prostate cancer and a positive image does not confirm the presence of prostate cancer. The performance of gallium Ga 68 gozetotide for imaging of biochemically recurrent prostate cancer seems to be affected by serum PSA levels and by site of disease. The performance of gallium Ga 68 gozetotide for imaging of metastatic pelvic lymph nodes prior to initial definitive therapy seems to be affected by Gleason score. Gallium Ga 68 gozetotide uptake is not specific for prostate cancer and may occur with other types of cancer as well as non-malignant processes such as Paget’s disease, fibrous dysplasia, and osteophytosis. Clinical correlation, which may include histopathological evaluation of the suspected prostate cancer site, is recommended.  

Radiation Risks: Gallium Ga 68 gozetotide contributes to a patient’s overall long-term cumulative radiation exposure. Long-term cumulative radiation exposure is associated with an increased risk for cancer. Ensure safe handling to minimize radiation exposure to the patient and health care workers. Advise patients to hydrate before and after administration and to void frequently after administration. 

Adverse Reactions: The most commonly reported adverse reactions were nausea, diarrhea, and dizziness, occurring at a rate of < 1%. 

Drug Interactions: Androgen deprivation therapy (ADT) and other therapies targeting the androgen pathway, such as androgen receptor antagonists, can result in changes in uptake of gallium Ga 68 gozetotide in prostate cancer. The effect of these therapies on performance of gallium Ga 68 gozetotide PET has not been established. 

OVERDOSAGE 

In the event of an overdose of gallium Ga 68 gozetotide, reduce the radiation absorbed dose to the patient where possible by increasing the elimination of the drug from the body using hydration and frequent bladder voiding. A diuretic might also be considered. If possible, an estimate of the radiation effective dose given to the patient should be made. 

Adequate Hydration: Instruct patients to drink a sufficient amount of water to ensure adequate hydration before their PET study and urge them to drink and urinate as often as possible during the first hours following the administration of Gallium Ga 68 Gozetotide Injection, in order to reduce radiation exposure. 

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit MedWatch at www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report adverse reactions to Telix by calling 1-844-455-8638 or emailing pharmacovigilance@telixpharma.com.

For important risk and use information about ILLUCCIX® Injection, please see full Prescribing Information.

References: 1. Illuccix (kit for the preparation of gallium Ga 68 gozetotide injection) prescribing information. 2. Massat MB. Nuclear medicine prepares for greater 68Ga demand. Appl Radiol. 2021;50(2):30-31. https://appliedradiolo-gy.com/articles/nuclear-medicine-prepares-for-greater-ga-68-demand. Accessed July 13, 2021. 3. Velikyan I. 68Ga-Based radiopharmaceuticals: production and application relationship. Molecules. 2015;20(7):12913-12943.